Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs.
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چکیده
منابع مشابه
Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs.
Antiarrhythmic drugs may aggravate or even induce ventricular arrhythmias. This type of adverse reaction is becoming more prevalent as the use of antiarrhythmic agents becomes more widespread. In a retrospective analysis of antiarrhythmic drug action, a worsening of arrhythmia was observed in 80 of 722 (11.1%) antiarrhythmic drug tests in 53 of 155 patients being treated for ventricular tachyar...
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or quinidine. Two dose schedules were employed; procaine amide, 3.0 and 6.0 g daily and quinidine, 1.2 and 1.8 g daily. Though adequate and even high drug blood levels were reached, an effective antiarrhythmic response was observed in only eight patients receiving procaine amide and in seven of those taking quinidine. These modest successful results were associated with a high incidence of trou...
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ژورنال
عنوان ژورنال: Circulation
سال: 1982
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.65.5.886